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2. Type of concomitant neuroleptic treatment.

Neuroleptic drugs differ in their affinity for cholinoceptors. Neuroleptic drugs from the butyrophenone family have low affinity for cholinoceptors, while some phenothiazines (e.g. thioridazine) have high affinity for cholinoceptors. Whether or not anticholinergic drugs are needed, and the doses required, should be balanced with the degree of anticholinergic action needed with a particular neuroleptic. Thus for example, addition of a concomitant anticholinergic drug may not be required with a neuroleptic like thioridazine.