Napoli, Centro Congressuale Stazione Marittima

29 maggio - 1 giugno 2002

Mercoledì 29.05.02

Ore 09.00 — 10.00 Registrazione partecipanti

SESSIONE ORALE

Ore 10.00 — 11.30 ENCEFALOPATIE ISCHEMICHE E TRAUMATICHE

Evidence of calpain and caspase-3-like activation in CSF of severe human traumatic brain injury

M. Aguennouz, F. Angileri, D. d’Avella, O. de Divitiis, A. Germanò, A. Toscano, F. Tomasello, and G. Vita (Messina)

CADASIL and cerebrovascular diseases

S. Bianchi, A. Rufa, ML Stromillo, N. De Stefano, C. Battisti, D. Inzitari, P. Lo Giudice, A. Malandrini, L Pantoni, F. Sicurelli, MT Dotti and A. Federico (Siena, Firenze)

Cell-permeable peptides that inhibit JNK action give strong protection against exitotoxicity and ischemia

T. Borsello, M. Repici C. Bonny, A. Vercelli and P.G.H. Clarke (Losanna, Torino)

The novel poly(ADP-Ribose)polymerase (PARP) inhibitor thieno[2,3-c]-isoquinolin-5-one (TIQ) attenuates neuronal injury following focal ischemia in rats

A. Cozzi, M. Pangallo, E. Camaioni, R. Pellicciari, D.E. Pellegrini-Giampietro and F. Moroni (Firenze, Perugia)

In situ demonstration of oxidative damage and apoptosis in an experimental model of global transient cerebral ischemia in the rat

A. Mauro, M. Aragno, L. Pradotto, O. Danni and G. Boccuzzi (Piancavallo-VB, Torino)

The Na+/Ca2+ exchanger (NCX) in the Na+ efflux-Ca2+ influx mode of operation exerts a neuroprotective role in a model of in vivo cerebral ischemia

A. Tortiglione, G. Pignataro, I. Petriello, G.F. Di Renzo, S. Amoroso and L. Annunziato (Napoli)

Ore 11.30 — 12.00 LETTURA MAGISTRALE

"Possibili strategie farmacologiche per limitare il danno cerebrale

post-ischemico"

Flavio Moroni (Firenze)

Ore 12.00 — 12.30 Coffee break

Ore 12.30 — 13.30 PATOLOGIE INFIAMMATORIE DEL S.N.C.

IFNbeta bioavailability is significantly reduced by Neutralizing antibodies (NAbs)

A. Di Sapio, F. Gilli, A. Sala, M. Capobianco, E. Milano, S. Malucchi, R. Bottero, F. Melis, A. Bertolotto and M.T. Giordana (Torino)

Characterization of T cells homing into the CSF of subjects with inflammatory diseases of the CNS

D.Giunti , G. Borsellino , M. Marchese, E Capello, E. Pedemonte, M.T. Valle , L. Battistini, G.L Mancardi and A. Uccelli (Genova, Roma)

Trascriptional analysis of MS brain lesions

A. Uccelli, B. Shaikh, E. Capello, L. Nobbio, J. Sedgwick and G. Mancardi (Genova, Palo Alto)

Paraneoplastic cerebellar degeneration with YO antibodies: clinical findings and follow up of 14 patients

R. Vitaliani, M. Vianello, E. Nardelli, B. Tavolato and B.Giometto (Padova, Verona)

Ore 13.30 — 14.30 Intervallo

Ore 14.30 —16.15 PATOLOGIE DEL NERVO PERIFERICO

Painful neuropathy, monoclonal gammopathy and amyloid deposits: response to treatment in 3 cases

C. D'Avino, G. Siciliano, V. Panichi, A. Azzarà, A. Del Corona, L. Pollina and L. Murri (Pisa)

Charcot-Marie-Tooth disease (CMTX): an immunohistochemical analysis of connexin 32 (Cx32) expression in nerve biopsies

G.M. Fabrizi, T. Cavallaro, F. Taioli, A. Uncini and N. Rizzato (Verona, Chieti)

Cytoskeletal characterization of cutaneous nerves

G. Lauria, R. Lombardi, M. Morbin, M. Borgna, A. Sghirlanzoni and D. Pareyson

(Milano)

Expression and distribution of inflammatory markers NF-kB and C5b-9 in peripheral neuropathies of different origin

1. Mazzeo, M. Laurà, M. Aguennouz and G. Vita (Messina)

Cytotoxic effects of Schwann cells. Implications for PNS inflammatory diseases

G. Moretto, G. Ossi, P. Valdo, L. De Toni and B. Bonetti (Belluno, Verona)

Pathological alterations and mRNA expression for PMP22 and P0 in peripheral nerves of patients with CMT1

S. Sampaolo, L. De Martino, A. Budillon, T. Bardaro, C. Tucci, M. D'Urso and G. Di Iorio (Napoli)

Altered dosage of peripheral myelin protein 22 (PMP22) affects myelin periodicity

A. Schenone, L. Nobbio, M. Grandis, L. Benedetti, G.F. Gherardi, M. Abbruzzese, Mancardi GL, and C. Riekel (Genova, Grenoble)

Ore 16.15 — 16.45 Coffee break

Ore 16.45 — 17.45 PATOLOGIE DEI MOTONEURONI

Autosomal recessive spastic paraplegias in 19 families from Southern Italy

M. Carella, A. Filla, V. Scarano, C. Mollica, C. Criscuolo, C. Rizzo, L. Santoro, M. Orio, A. Perretti, G. Coppola and G. De Michele (Napoli)

Alteration of kinesin distribution in motorneuronal processes containing aggregates of androgen receptor with an elongated polyglutamine tract

F. Piccioni, S. Simeoni, P. Pozzi, A. Rigotto, V. Targa, L. Martini, and A. Poletti (Milano)

Can hematopoietic stem cells repair the central nervous system?
V. Silani, L. Cova, J. Sassone, L. Mantegna and A. Ratti (Milano)

Mitochondrial enzyme activity and neural nitric oxide syntethase in skeletal muscle of patients with amyotrophic lateral sclerosis

G. Sorarù, L. Vergani, N. Cimini, C. D’Ascienzo, G. Moretto and C. Angelici (Padova, Belluno)

Ore 17.45 — 18.15 LETTURA MAGISTRALE

"New insights in the diagnostic of leukodystrophies"

Odile Boenspflug Tanguy (Clermont-Ferrand)

SESSIONE POSTER

Ore 18.15 — 19.15 ENCEFALOPATIE ISCHEMICHE

Effects of selective COX-2 inhibition on the evolution of cerebral damage induced by focal cerebral ischemia in spontaneously hypertensive rats

G. Mariucci, C. Passeri, M. Tantucci, S. Fredduzzi and M.V. Ambrosini (Perugia)

Astroglial responses and metallothionein-I-II in Binswanger’s subcortical encephalopathy

G. Sancesario, P. Zambenedetti, H. P. Schmitt, and P. Zatta (Roma, Dolo-Venezia, Heidelberg Padova)

Anoxic preconditioning improves mitochondrial activity, and reduces nNOS expression and free radical production in cortical neurons exposed to OGD and OGD/reoxygenation

A.Scorziello, A.Gioielli, A. D’Alessio, R. Sirabella, A. Secondo, A. Ciafardini, G.F. Di Renzo and L. Annunziato ( Napoli)

Tumor necrosis factor-a polymorphism C-850T is not associated with Alzheimer's Disease and vascular dementia in an Italian population

L. Terreni, S. Fogliarino, C. Sala Frigerio, P. Quadri, R. Ruggieri, F. Piccoli, M. Tettamanti, U. Lucca and G. Forloni (Milano, Mendrisio, Palermo)

PATOLOGIE INFIAMMATORIE DEL S.N.C.

A 68-year-old woman with polymyalgia, dementia, and chronic meningoencephalitis

A. Giordano, G. Sancesario, P. Concorsi, A. Martorana, R. Massa, and G. Bernardi (Roma)

Central nervous system angiitis associated with Hepatitis C infection

M. Grandis, L. Roccatagliata, E. Capello, A. Uccelli, A. Schenone, A. Primavera and G.L. Mancardi (Genova)

Chronic meningitis as manifestation of sarcoidosis: three cases report

S. Marangoni, B. Tavolato and V. Argentiero ( Padova)

Cerebrospinal fluid examination during Neuromyelitis Optica (NMO) relapses

E. Milano, S. Malucchi, M. Capobianco, M. Iudicello, R. Bottero, F. Melis, A. Sala, F. Gilli, A. Bertolotto and M.T. Giordana (Torino)

PATOLOGIE DEL NERVO PERIFERICO

Sensory variant of acute demyelinating polyradiculoneuropathy with anti-GQ1b

A Barbieri, M Leone and G Galassi ( Modena)

Sensory-motor polyneuropathy in a patient with mitochondrial myopathy

L. Benedetti, M. Grandis, C. Bruno, M. Bado, M. Abruzzese, G.L. Mancardi, and A. Schenone (Genova)

PMP22: characterization of different missense mutations

M. Ferrarini, G. M. Fabrizi, T. Cavallaro, R. Chies, C. Brancolini and N. Rizzato (Udine, Verona)

Sural nerves of Charcot-Marie-Tooth disease type 1A (CMT1A) patients overexpress erbB receptors

R. Massa, C. Palumbo, R. Bei, T. Cavallaro, M.B. Panico, N. Rizzuto, G. Bernardi and A. Modesti (Roma, Verona)

Alpers-Huttenlocher disease and peripheral neuropathy

A. Simonati, G. Tomelleri, E. Fincati, M. Pampanin, M. Filosto, P. Tonin and N. Rizzuto (Verona)

A case of vasculitic neuropathy with extensive B lymphocytes infiltration in sural nerve biopsy

C. Solaro, L. Benedetti,, M. Grandis, G.F. Gherardi, L. Banchi, P. Tanganelli, D. Venuti, U. Filippi, M. Abruzzese, G.L. Mancardi and A. Schenone (Genova)

Relapsing chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) preceding colorectal cancer

R. Suozzi, A. Ariatti and G. Galassi (Modena)

PATOLOGIE DEI MOTONEURONI

Erythropoietin preserves motor function in a transgenic mouse model of familial ALS

G. Grignaschi, E. Zennaro, N. Calvaresi, P. Ghezzi, A. Cerami and C. Bendotti (Milano, New York)

A Neapolitan family with a new nonsense mutation of the SPG4-gene

Ph. La Marca, M.A.B. Melone, E. Buffone, F. Taroni and R. Cotrufo (Napoli, Milano)

Ore 19.45 Cerimonia di apertura

Giovedì 30.05.02

Corso di perfezionamento: discussione clinico-patologica

Ore 08.30 - 10.30 Encefalopatie spongiformi:

diagnostica e diagnostica differenzialE

coordinato da Orso Bugiani ( Milano)

Ore 11.00 — 11.30 Coffee break

Ore 11.30 — 13.30 Leucodistrofie

coordinato da Marina Melone ( Napoli)

Ore 13.30 — 14.30 Intervallo

Ore 14.30 — 16.30 Miopatie metaboliche

coordinato da Roberto Cotrufo (Napoli)

Ore 16.30 — 17.00 Coffee break

Ore 17.00 — 19.00 TRE ARGOMENTI IN TEMA DI APPROCCIO

PRATICO AI GLIOMI INTRACRANICI

coordinato da Alessandro Mauro (Torino)

Ore 20.15 Cena sociale

Venerdì 31.05.02

SESSIONE ORALE

Ore 08.30 — 10.30 MALATTIE DEL MUSCOLO

Histopathological features of Myotonic Dystrophy type 2 (DM2/PROMM)

G. Bassez, P. Laforet, A. Rouche, T. Maisonobe, R. Krahe, R. K. Gherardi, M. Fardeau, and B. Eymard (Paris, Creteil)

Cytogenetic and oxidative damage in patients affected by mitochondrial encephalomiopathies

M. Mancuso, G. Siciliano, A. Naccarati, S. Molinu, A. Del Corona, S. Tovani, L. Pasquali and L. Migliore (Pisa)

c-Myc downregulation by Transforming Growth Factorß (TGFß) is required for activation of the p15Ink4b arrest pathway in DMD myoblasts

M.A.B. Melone, G. Peluso, U. Galderisi, O. Petillo, F.P. Jori, and R. Cotrufo (Napoli)

Nuclear factor KAPPA B expression in inflammatory myopathies

M.C. Monici, M. Aguennouz, A. Mazzeo and G. Vita (Messina)

Dysferlin abnormalities: morphological and clinical findings

L. Morandi, M. Mora, R. Mantegazza, C. Sala, E. Sanna, P. Dassi and F. Cornelio (Milano)

Oxidative stress in human aged skeletal muscle: relationship with the distribution of type II fibers

O. Pansarasa, B. Marzani, G. Felzani, J. Vecchiet and F. Marzatico (Pavia)

Evidence of oxidative stress "in vivo" in patients with myotonic distrophy

A. Paolicchi, G. Siciliano, A. Del Corona, S. Tovani, B. Solito, M. Falorni, A. Rocco, G. Malvadi and A. Pompella (Pisa)

Focal muscle involvment in polimyositis or focal myositis? A report of three cases

C. Rodolico, A. Mazzeo, A. Toscano, M. Gaeta, A. Migliorato, C. Messina and G. Vita (Messina)

Ore 10.30— 11.00 Coffee break

Ore 11.00— 11.30 LETTURA MAGISTRALE

"L'évolution actuelle du concept de "myopathie congénitale"

Michel Fardeau (Parigi)

Ore 11.30 — 13.30 NEUROBIOPATOLOGIA CELLULARE E MOLECOLARE

Heparan sulphate proteoglycan triggers production of NO and TNFa from murine microglia

S. Bussini, P. Baron, L. Meda, P. Fratta, S. Livraghi, M. Tiriticco, S. Sanzone, E. Scarpini and G. Scarlato (Milano)

Involvment of autophagic-lysosomial compartment in cerebellar granule neurons undergoing apoptosis

N. Canu, A.L. Serafino, G. Amadoro, M.T. Ciotti, C. Barbato and P. Calissano (Roma)

Increased Notch2 expression in hippocampus of adult mouse after kainate treatment

B.Damiani, G. Ferrari-Toninelli, M. Codenotti, M. Quarto, G. Lozza, M. Grilli and M. Memo (Brescia)

Differentiation and apoptosis of rat neural stem cells: a molecular and immunocytochemical follow-up

F.P. Jori, U. Galderisi, E. Piegari, G. Peluso, R. Cotrufo and M.A.B. Melone (Napoli)

Histidine 578 and 587 in the S5-S6 linker of hERG1 K+ channels confer sensitivity to reactive oxygen species

A.Pannaccione, P. Castaldo, L. Annunziato and M. Tagliatatela (Napoli)

Myoclonic epilepsy is mediated by antibodies anti-GluR3 in human cerebral GvHD

L. Roccatagliata, R. Mantegazza, E. Capello, M. Cilli, B. Giometto, P. Bernasconi, G. Mancardi, C. Solaro and Uccelli A. (Genova, Milano, Padova)

Induction and differentation of dopaminergic neurons in vitro

F. Volpicelli, C. Perrone-Capano and U. di Porzio (Napoli)

Expression profiling in mouse neural development and differentiation

M. Zollo, A. Faedo, V.Aglio, and A. Bulfone (Napoli, Milano)

Ore 13.30 — 14.30 Intervallo

SESSIONE POSTER

Ore 14.30 — 15.30 MALATTIE DEL MUSCOLO

Inflammation in dysferlin myopathy: immunopathological study of 15 patients

P. Confalonieri, R. Lorenzoni, L. Oliva, F. Andreetta, M. Mora, L. Morandi, and

R. Mantegazza (Milano)

Large cardio-embolic Ischemic stroke in KEARNS-SAYRE Syndrome

C. Coppola , M. Fratta , A. Gallo, M.A.B. Melone, F. Santorelli, S. Sampaolo and R. Cotrufo (Napoli, Roma)

Familial Dominant Inclusion Body Myopathy associated with Mental Retardation and Cerebellar Atrophy

M. T. Dotti, A. Malandrini, S. Gambelli and A. Federico (Siena)

Mitochondrial neuro-gastrointestinal encephalomyopathy syndrome : clinical and pathological findings in two siblings affected

M. Fratta, G. Di Iasi, V. Sannino, G. Di Iorio and R. Cotrufo (Napoli)

Association of vocal cords hypotonia and Calpain-3 deficiency in a patient with limb-girdle muscular dystrophy

R. Lanzillo, F. Vitale, M. Aguennoz, G. Vita and L. Santoro (Napoli, Messina)

Carnitine Palmitoyltransferase II deficiency associated with tubular aggregates

O. Musumeci , M.C. Monici , M. Aguennouz, C. Rodolico, G. Vita and A. Toscano (Messina)

Adenine nucleotide translocator-1 (ANT-1) mutation in autosomal dominant progressive external ophthalmoplegia with psychotic disorder: report of a family

G. Siciliano, M. Mancuso, F.M. Santorelli, A. Tessa, S. Petrini, F. Malandrini and L. Murri (Pisa, Roma, Siena)

Myopathy and muscle carnitine deficiency in a patient with low serum testosterone

A.Toscano, O. Musumeci, C. Rodolico, M. Aguennouz and G. Vita (Messina)

NEUROBIOPATOLOGIA CELLULARE E MOLECOLARE

Role of TAU integrity on neuronal survival

G. Amodoro, A. Sacco, C. Barbato, M.T. Ciotti. P. Calissano and  N. Canu (Roma)

Expression pattern of the K+ channel subunits encoded by the ether-A-GOGO related (ERG) genes ERG1, ERG2 AND ERG3 in the rat brain

F. Boscia, A. Canitano, P. Castaldo, M. Papa and M. Tagliatatela (Napoli)

Differential expression of the Na+-Ca2+ exchanger-encoding genes in the rat central nervous system

A Canitano, F. Boscia, P. Castaldo, M. Papa and L. Annunziato (Napoli)

Neuropathological effects of apomorphine are attenuated by risperidone in mongolian gerbil

G. Donato, G. Ferraro, N. Costa, A. Amorosi, L. Maltese, L. Volpentesta, E. Perrotta, S. Tripepi, G.B. De Sarro, Catanzaro (Cosenza)

Caffeic acid phenethyl ester blocks apoptosis induced by low potassium in cerebellar granule cells
E. Esposito, D. Rotilio, A. Giorgini and S. Algeri, Santa Maria Imbaro (Chieti)

Synaptic protein synthesis: modulation by age and training

M. Eyman, Z. Scotto Lavina, M. Crispino, S. Piscopo and A. Giuditta (Napoli)

Neurotensin and Enkephalin expression in rat globus pallidus following 6-hydroxydopamine lesion of substantia nigra

A.Martorana, F. R. Fusco, V. D’Angelo, G. Bernardi and G. Sancesario (Roma)

Immunoreactivity of GAD-Ab positive sera on rat hippocampal neurons in culture

M. Vianello, S.Vassanelli, C. Mucignat and B. Giometto (Padova)

PATOLOGIE GENETICO-METABOLICHE

Neuropathology of lysosomal storage diseases in domestic mammals

C. Cantile, A. Simonati, F. Gismondi and M. Aruspici (Pisa, Verona)

Globoid cell leukodystrophy in two West Highland white terriers

M.T. Capucchio, S. Amedeo, D. Catalano, E. Cornaglia, M. Galloni, D. Lotti, P. Pregel, M. Prunotto and A. Valazza (Torino)

Progressive multifocal leukoencephalopathy (PML) in a adult patient with ICF syndrome

M. Colucci, A. Schenone, A. Beronio, S. Pretta, P. Fontana, L. Cocito, C. Serrati, G.L. Mancardi and E. Capello (Genova)

Autosomal dominant late-onset leukoencephalopathy with Pelizaeus-Merzbacher phenotype

L. Palmucci, D. Duò, A. Ferraiolo, M. T. Rinuado, M. Piccinini, S. Baldovino, G. Vaula, S. Leombruni and M. T. Giordana (Torino, Ivrea)

SESSIONE ORALE

Ore 15.30 — 17.30 TUMORI DEL S.N.C.

Cyclins D1 and 27/Kip.1 in the differential diagnosis of diffuse astrocytomas and oligodendrogliomas

V. Fiano, C. Ghimenti, P. Cavalla and D. Schiffer (Torino)

p14ARF/Mdm2/p53 pathway deregulation in two glioblastoma series: with and without differentiated areas

B.Ghimenti, V. Fiano, L. Chiadò-Piat, P. Cavalla and D. Schiffer (Torino)

Expression of Microtubule-Associated Protein-2 (MAP-2) in Normal Human Brain and Gliomas

F. Giangaspero, F. Morigi, G. Cenacchi, P. Wesseling and B. Jacobs (Roma, Cesena, Bologna, Nijmegen)

Adult and pediatric medulloblastomas have different molecular prognostic

indicators

M.T. Giordana, D. Duò, S. Gasverde, I. Morra, S. Cristina, S. Sandri, L. Cordero, M. Lanotte and A. Chiò (Torino, Novara)

Clinical features of gliomas of the chiasma. A retrospective study of a

series of 11 patients

G. Lama, G. Tirino, C. Grassia, E. Calabrese, A. Scuotto and M.A.B. Melone (Napoli)

Germ cell tumors: expression of adhesion molecules in 40 cases

B.Pollo, L. Valentini, M. Massimino, A. Dellarole (Milano)

Turcot's syndrome: two case reports

L. Pradotto, G. Albani, G. Miscio, S. Baudo, L. Priano, B. Pollo and A. Mauro (Piancavallo, Milano)

Evaluation of thin-layer methods in cerebrospinal fluid cell preparation

F. Sanguedolce, A. Cimmino, L. Tantimonaco and R. Ricco (Bari)

Ore 17.30 — 18.00 Coffee break

Ore 18.00 — 18.30 LETTURA MAGISTRALE

"Proliferazione e morte cellulare all'interfacies genotipo/fenotipo nei
gliomi"

Davide Schiffer (Torino)

SESSIONE ORALE

Ore 18.30 — 19.15 PATOLOGIE GENETICO-METABOLICHE

Functional consequences of point mutations in the KCNQ2 gene causing benign familial neonatal convulsions
P. Castaldo, E. Miraglia del Giudice, G. Bellini, G. Coppola, A. Pascotto, L. Annnunziato and M.  Taglialatela (Napoli)

Genetic analysis of two Italian Families with non specific X-mental retardation.

M.G. Miano, I. Annunziata, F. Di Leva, G. Fimiani, S. Russo, F. Cogliati, G. Casari, V. Ventruto, A. Ciccodicola, M.V. Ursini and M. D'Urso (Napoli, Milano)

Molecular Characterization of Twelve Patients with Megalencephalic Leukoencefalopathy with Subcortical Cysts
C. Patrono, G. Di Giacinto, F.M. Santorelli, O. Boespflug-Tanguy and E. Bertini (Roma, Clermont-Ferrand)

Ore 19.15 Assemblea dei soci

Sabato 01.06.02

SESSIONE ORALE

Ore 08.30 — 09.45 PATOLOGIE NEURODEGENERATIVE

Alpha-synuclein and Parkinson’s disease: a study using sinthetic peptides

1. Bertoli, I. Bertani, R. Invernizzi and G. Forloni (Milano)

A familial tauopathy with epilepsy and leukoencephalopathy

O. Bugiani, G. Giaccone, G. Sacco, M. Morbin, M. Mangieri, G. Rossi, G. Di Fede, M. Savoiardo and F. Tagliavini (Milano, Genova, Napoli)

Tissue Transglutaminase: a possibile role in Huntington disease

G. Peluso, A. Giordano, F.P. Jori, O. Petillo, S. Margarucci, P. Grippo, R. Cotrufo and M.A.B. Melone (Napoli)

Polyglutamine tract expansion in the androgen receptor in spinobulbar muscular atrophy

Simeoni S., Piccioni F., Pozzi P, Rigotto A., Targa V, Martini L, Poletti A. (Milano)

A familial autosomal dominant disease associated with intracytoplasmic and intranuclear ferritin accumulation

R. Vidal, M.B. Delisle, M. Takao, L. Miravalle, E. Uro-Coste, J.J. Liepnieks, M. Yazaki, V. Siani, P. Piccardo, P. Calvas, J. Murrell, M.D. Benson, O. Rascol and B. Ghetti (Indianapolis, Toulouse)

SESSIONE POSTER

Ore 09.45 — 10.45 TUMORI DEL S.N.C.

Modulation of vascular endothelial growth factor (VEGF) expression in C6 glioma cell cultures: novel strategies using solid lipidic nanoparticles (SLN) vehiculating antisense oligonucleotides (ODN)

A.Brioschi, S. Calderoni, L. Pradotto, M. Guido, E. Ugazio, M.R. Gasco and A. Mauro (Verbania, Torino)

Solid lipidic nanoparticles vehiculating doxorubicin and colloidal FE2+ in C6 glioma cell cultures: confocal and electron microscopy study

S. Calderoni, A. Brioschi, M. Guido, L. Pradotto, G. Azan, F. Blasi, D. Zanetti, R. Cavalli, M.R. Gasco, and A. Mauro (Verbania, Torino)

F-box protein Skp2 is not the only pathway for p27/Kip.1 degradation

P. Cavalla, V. Fiano, C. Ghimenti, R. Mutani and D. Schiffer (Torino)

Brain surface ependymoma: report of two cases

G. Cenacchi, F. Roncaroli and A. Fioravanti (Bologna)

MIB-1 labeling index has no prognostic value in craniopharingiomas

D. Duò, E. Trevisan, F. Benech and M. T. Giordana (Torino)

Neuroblastoma with symptomatic spinal cord compression at diagnosis: experience by Service of Pediatric Oncology-2nd University of Neaples (1997-99 AIEOP protocols)

M. Giuliano, M.A.B. Melone, R. Mastroianni, E. Calogero, C. Morgera and F. Casale (Napoli)

Efficacy of systemic treatment with doxorubicin incorporated in Solid Lipidic Nanoparticles in a rat C6 glioma brain tumor model

M. Guido, A. Brioschi, L. Pradotto, F. Zenga, G.P. Zara, R. Cavalli, M. R. Gasco and A. Mauro (Torino, Verbania)

Solitary fibrous tumor of the cerebellopontine angle: a case report

G. Parisi, A. Cimmino, M. G. Fiore, V. Troccoli, and R. Ricco (Bari)

Meningeal carcinomatosis: a post-mortem diagnosis

R. Rovati, G. Ficarra, N. Mongiardo, T. Artusi and G. Galassi (Modena)

Extracranial metastases in oligodendrogliomas: clinical and molecular genetic data

E. Trevisan, C. Ghimenti, M. Judicello, E. Leonardo, R. Boldorini, I. Balteri and M.T. Giordana, Torino, Orbassano (Novara)

PATOLOGIE NEURODEGENERATIVE

Cholesterol Levels and APP processing in controls and in AD patients: evidence from the platelet model

B. Borroni, F. Colciaghi, G. L. Lenzi, L. Caimi, F. Cattabeni, M. Di Luca and A. Padovani (Brescia, Milano, Roma)

Novel Proteinase-K resistant fragments of PrPSc in sporadic Creutzfeldt-Jakob disease

A. Farinazzo, G. Zanusso, S. Ferrari, M. Fiorini, M. Gelati, P.G. Righetti, M.S. Sy, N. Rizzuto and S. Monaco (Verona, Cleveland)

Intrafamilial phenotipic variability in a new Italian kindred with Gerstmann-Straussler-Scheinker disease with the PlO2L mutation

A.Filla, B. Ghetti, G. Coppola, A. De Falco, M. Pocchiari, R. Petraroli, C. Casali, M.Orio, G. Caneve, M. Manfredi and G. De Michele (Napoli, Roma, Belluno, Indianapolis)

Neurotoxic and gliotrophic properties of synthetic prion protein (PrP) peptide PrP82-146

L. Fioriti, N. Angeretti, M. Morbin, O. Bugiani, F. Tagliavini, M. Salmona, R. Chiesa, and G. Forloni (Milano)

Tetracyclines in Alzheimer disease models

G. Forloni, L. Colombo, N. Angeretti, M. Colovic, S. Caccia, G. Giaccone, O. Bugiani, F. Tagliavini and M. Salmona (Milano)

Blood homocysteine assay in Alzheimer disease and vascular dementia

M. Gallucci, A. Zanardo, L. De Valentin and A. Staunovo Tacca (Treviso, Padova)

A713T mutation of the b PP gene in an Italian family with Alzheimer disease and severe congophilic angiopathy

G. Giaccone, G. Rossi, M. Morbin, A. Bruni, F. Tagliavini and O. Bugiani (Milano, Lamezia Terme)

Relationship between nature of the amino acid change at position 22 of Alzheimer’s Aβ peptide and amyloidogenesis

M. Morbin, G. Mazzoleni, J Ghiso, O. Bugiani, F. Tagliavini (Milano, NewYork)

The increased production of Ab 42 following endoplasmic reticulum stress isnot influenced by presenilin 1 mutations

A. Piccini, A. Fassio, A. Vitali, A. Assini, R. Borghi, S. Sorbi, P.D. Mehta, R. Sitia and M. Tabaton (Genova, Milano, Firenze, Staten Island)

Ore 10.45— 11.15 Coffee break

SESSIONE ORALE

Ore 11.15 — 13.45 DEMENZE DEGENERATIVE E MALATTIE DA PRIONI

Neuronal inclusions in familial frontotemporal dementia

A.C. Bruni, K.H. El Hachimi, T. Kawarai, M.G. Spillantini, P.H. St George Hyslop, A. Leotta, S. Lio and J.F. Foncin (Lamezia Terme, Paris, Toronto, Cambridge)

Co-occurrence of two PrPSc types in a single flock of sheep and goat with scrapie

M. Fiorini, C. Casalone, P. Acutis, E. Bozzetta, A. Farinazzo , M. Gelati, G. Zanusso, S. Ferrari, S. Monaco and M. Caramelli (Torino,Verona)

Neurotoxic and gliotrophic properties of synthetic prion protein (PrP) peptide PrP82-146

L. Fioriti, N. Angeretti, M. Morbin, O. Bugiani, F. Tagliavini, M. Salmona, R. Chiesa, and G. Forloni (Milano)

Chemokine levels in CSF and serum from demented patients

D. Galimberti, N. Schoonenboom, E. Scarpini, P. Scheltens and the DIACR# Group (Milano, Amsterdam)

Pathologic prion protein in an asymptomatic carrier of a PRNP mutation

P. Piccardo, F. Unverzagt, A. William, M. Takao, S. Dlouhy, M.R. Farlow and B. Ghetti. (Indianapolis)

Effects of the nitric oxide donor molsidomine on cognition

N.Pitsikas, A.E. Rigamonti, S.G. Cella and E.E. Muller (Milano)

Perisomatic granules of hippocampal CA1 neurons in Alzheimer’s disease and Pick’s disease

A. Probst, M.C. Herzig, C. Mistl, S. Ipsenam and M. Tolnay (Basel, Switzerland)

Soluble amyloid b -protein is increased in frontotemporal dementia associated with TAU gene mutations

M. Tabaton, A. Vitali, R. Borghi, G. Perry, S. L.Siedlak, L. Giliberto, D. Zaccheo and B. Ghetti (Genova, Cleveland, Indianapolis)

Physicochemical and biological properties of a synthetic "miniprion"

F. Tagliavini, V. Bonetto, T. Massignan, R. Chiesa, M. Morbin, G. Mazzoleni, L. Diomede, L. Colombo, G. Forloni and M. Salmona (Milano)

Development and characterization of PC12 cell lines allowing inducibile expression of prion protein protein carrying pathogenic mutations

E. Quaglio, G. Forloni, and R. Chiesa (Milano)

Ore 13.45 — 14.00 Conclusioni